Acknowledgments
- In recent years, the use of food-safe titanium dioxide (TiO2) has become increasingly prevalent in the manufacturing of various food products. TiO2 is a naturally occurring compound that is widely used as a pigment due to its whiteness and brightness. However, concerns have been raised regarding its safety when used in food products.
EFSA’s scientific advice will be used by risk managers (the European Commission, Member States) to inform any decisions they take on possible regulatory actions.
TiO2 comes in many different forms. However, only a few of these forms are considered food-grade (acceptable to be added to food). Many studies that raised concern about the safety of TiO2, including the concern for genotoxicity, used forms of TiO2 that are not considered acceptable for use in food and have different properties than food-grade TiO2. Other studies did use food-grade TiO2, but took steps to break the material down into smaller particles than what would normally be found in food.
Tio2 Powder CR-930 Titanium Dioxide Free Sample
Magnesium can be made by several methods (Fig. 1), but the most common method of manufacture is by the electrolytic process, as for example the electrolysis of magnesium chloride.
The refractive index, represented by the letter n, of a material describes how light propagates through and is bent by, that material. The magnitude of the refractive index, depending upon the electronic structure of the molecules, governs to what extent the path of light changes, when entering or leaving a material.
Particles in a matrix, like pigment particles surrounded by the binder system in a coating, ink or plastic, can change the propagation direction of light when the particles and the matrix have a different refractive index. This phenomenon, called scattering, results in both white color (provided that the particles do not absorb visible light) and the hiding power of the coating.
Manufacturers of titanium dioxide play a crucial role in meeting the global demand for this versatile substance. They employ advanced manufacturing processes and technologies to produce high-quality titanium dioxide with consistent properties and performance. Many manufacturers also invest in research and development to explore new applications and improve existing products.
In a study published in the journal Food and Chemical Toxicology in 2016, researchers investigated whether titanium dioxide exposure led to an increase in colorectal tumor creation in mice by using a colitis associated cancer model. By measuring tumor progression markers, the researchers found that mice given titanium dioxide experienced enhanced tumor formation in the distal colon. There was also a decrease of cells that act as a protective barrier in the colon. The researchers wrote: “These results suggest that E171 could worsen pre-existent intestinal diseases.”
Par ailleurs, dès lors que l'on recherche une certain transparence dans les travaux artistiques, son pouvoir opacifiant et son pouvoir dégradant des couleurs pas trop élevés le désignent pour remplacer le dioxyde de titane trop opaque et trop dégradant (§ Des Liants et des couleurs aux éditions EREC)

Titanium is a metal element found naturally in the environment. When it's exposed to oxygen in the air, it forms titanium oxides that are contained in many minerals, sands, soils, and dusts.
In the meantime, the chemical factories of Continental Europe, principally in Germany, Austria and Belgium, had taken hold of the novelty and under the collective name of lithopone or lithophone, by numerous processes, produced various grades of the pigment, branding the respective qualities as red seal, green seal, yellow seal, blue seal, etc., or selling them under some fancy name. Of this we shall speak later on. The crusade against the use of white lead in the various countries of Continental Europe, assisted the manufacturers, to a very great extent, in marketing their products, not only to industrial concerns, as has been the case in this country, until recently, but to the general painting trade. Up to 1889 the imports into this country were comparatively small. At that time one of the largest concerns manufacturing oilcloth and linoleum in the State of New Jersey began to import and use Charlton white. Shortly after that other oilcloth manufacturers followed suit, replacing zinc white with lithopone in the making of white tablecloth, etc., and later on abandoning the use of white lead in floor cloth and linoleum. This gave an impetus to several chemical concerns, that erected plants and began to manufacture the pigment. Competition among the manufacturers and the activity of the importers induced other industries to experiment with lithopone, and the shade cloth makers, who formerly used white lead chiefly, are now among the largest consumers. Makers of India rubber goods, implement makers and paint manufacturers are also consumers of great quantities, and the demand is very much on the increase, as the nature of the pigment is becoming better understood and its defects brought under control. Large quantities find their way into floor paints, machinery paints, implement paints and enamel paints, while the flat wall paints that have of late come into such extensive use owe their existence to the use of lithopone in their makeup.


Above 10%, 1 kg of TiO2 should be replaced by 1.3 kg of Lithopone 30%, reducing the amount of polymer accordingly.
In a 2021, Chinese researchers examined the impact of E171 on lipid digestion and vitamin D3 bioaccessibility in a simulated human gastrointestinal tract model. They examined Vitamin D’s bioaccessibility, or the amount it was released in the gastrointestinal tract, becoming available for absorption, and found it “significantly decreased from 80% to 74%” with the addition of E171. In the experiment, E171 decreased lipid digestion dose-dependently. Researchers wrote: “The findings of this study enhance our understanding toward the potential impact of E171 on the nutritional attributes of foods for human digestion health.” The study was published in the Journal of Agricultural and Food Chemistry,
R-895 pigment has good dispersing properties and can be easily and quickly dispersed into the binder solvent.
Because of its unique properties, titanium dioxide is widely used and is well known in nanoscience and nanotechnology. Titanium dioxide was one of the first materials to be used in nanotechnology products. However, the potential toxicity of titanium dioxide nanoparticles is a controversial subject. Many cosmetic companies use titanium dioxide nanoparticles. Because of its bright whiteness, it is used in products such as paints, coatings, papers, inks, toothpaste, face powder, and food colouring.
In both processes, the size of the pigment particles as well as the post-treatment is adjusted by fine-tuning the final steps in the chemical route.
Titanium Dioxide Rutile Tio2 POWDER Titanio Dioxide Pigment