- Titanium dioxide, with its chemical formula TiO2, is a naturally occurring compound that has been widely used in various industries due to its unique properties. This versatile white pigment is not only an essential ingredient in the manufacturing of paints, plastics, and coatings but also plays a crucial role in the production of sunscreens, food additives, and cosmetics.
Duan et al. administered 125 mg/kg BW or 250 mg/kg BW of anatase TiO2 (5 nm) intragastrically to mice continuously for 30 days. The exposed mice lost body weight, whereas the relative liver, kidney, spleen and thymus weights increased. Particles seriously affected the haemostasis of the blood and the immune system. The decrease in the immune response could be the result of damage to the spleen, which is the largest immune organ in animals and plays an important role in the immune response. Powel et al. demonstrated that TiO2 NPs may trigger immune reactions of the intestine after oral intake. They showed that TiO2 NPs conjugated with bacterial lipopolysaccharide, but not TiO2 NPs or lipopolysaccharide alone, trigger the immune response in human peripheral blood mononuclear cells and in isolated intestinal tissue. This indicates that TiO2 NPs may be important mediators in overcoming normal gut-cell hyporesponsiveness to endogenous luminal molecules, which may be particularly relevant to patients with inflammatory bowel disease, which is characterized by an abnormal intestinal permeability.
- In conclusion, wholesale lithopone B301 factories play a pivotal role in the global pigment industry by supplying a critical component used in numerous manufacturing processes. Their focus on quality, innovation, and sustainability ensures that they will continue to be vital contributors to the sector while balancing the need for economic growth with environmental responsibility.
CAS
Below 10% substitution, 1 kg of TiO2 should be replaced by 1 kg of Lithopone 30%.
The Process of Gravimetric Determination of TiO2
3.Used for coloring rubber products, varnishes, leather, paper, enamel, etc.

Prof Maged Younes, Chair of EFSA’s expert Panel on Food Additives and Flavourings (FAF), said: “Taking into account all available scientific studies and data, the Panel concluded that titanium dioxide can no longer be considered safe as a food additive . A critical element in reaching this conclusion is that we could not exclude genotoxicity concerns after consumption of titanium dioxide particles. After oral ingestion, the absorption of titanium dioxide particles is low, however they can accumulate in the body”.
Ultimately, it comes down to whether you want to take the risk of having Titanium Dioxide in your blood stream?
We have long been passionate about avoiding exposure to Titanium Dioxide & are proud that our products offer a safe alternative to Women everywhere. We strongly urge you to ditch your toxic, unsafe makeup & find a safer alternative.
In conclusion, the TiO2 industry supplier is an essential part of the supply chain for many industries that rely on this versatile pigment. By staying informed about market trends, investing in sustainable practices, and continuously improving their operations, TiO2 suppliers can continue to meet the growing demand for this essential material.
5. Geographical Availability Depending on the location of businesses, suppliers with a good logistical network can ensure timely delivery and availability of stock. Local suppliers may also provide cost advantages compared to international counterparts due to reduced shipping fees.
Benefits of Lithopone Powder:
Most notably, a European Food Safety Authority safety assessment published in May 2021 pointed to genotoxicity concerns, as suggested by previous research. Genotoxicity is the ability of chemicals to damage genetic information such as DNA, which may lead to cancer.
≤0.6
While the FDA maintains that the regulated use of titanium dioxide is safe, the European Food Safety Authority and some other experts warn of potential, serious health risks.

Lithopone, C.I. Pigment White 5, is a mixture of inorganic compounds, widely used as a white pigment powder. It is composed of a mixture of barium sulfate and zinc sulfide. These insoluble compounds blend well with organic compounds and confer opacity. It was made popular by the cheap production costs, greater coverage. Related white pigments include titanium dioxide, zinc oxide (zinc white), zinc sulfide, and white lead.[1]