Titanium dioxide nanoparticles may accumulate and cause DNA damage

With our strength and experience, we are confident that we can further provide our customers with more competitive Zns 28-30% Chemical Provide Lithopone Pigments Low Price and services. We have established a scientific quality control system, stricly obeyed in every process of the production, starting from the sourcing of raw materials to the dispatch of the final products. We pay attention to off-line visits and tracking, so as to better understand the effect of the product and optimize in a timely manner.

Specification:

For research published in 2022 study in the journal Food and Chemical Toxicology, scientists examined “the genotoxicity and the intracellular reactive oxygen species induction by physiologically relevant concentrations of three different TiO2 nanomaterials in Caco-2 and HT29-MTX-E12 intestinal cells, while considering the potential influence of the digestion process in the NMs’ physiochemical characteristics.” They found a “DNA-damaging effect dependent on the nanomaterial,” along with the micronucleus assay suggesting “effects on chromosomal integrity, an indicator of cancer risk, in the HT29-MTX-E12 cells, for all the tested TiO2 nanomaterials.” Researchers concluded that the results showcase “evidence of concern” regarding titanium dioxide used as a food additive.

In terms of titanium concentrate, the market in the Panxi region was quite stable in the first few weeks of the month. The overall state of the titanium ore market was satisfactory, and the price remained stable. The price of 38-grade titanium ore without tax was approximately 1,500-1,530 RMB/MT as of the 13th of January, while it was 2,220-2,260 RMB/MT for 46-grade titanium ore and 2,500-2,550 RMB/MT for 47-grade titanium ore.

Less frequently, we ingest E171 through liquids such as salad dressing, dairy products, and some artificially colored drinks. However, since E171 is insoluble, manufacturers must use other stabilizers to keep E171 suspended in liquids as an emulsion; otherwise, it will settle to the bottom. 

Anatase titanium dioxide is a popular ingredient in coatings due to its excellent UV resistance and chemical stability. Many manufacturers and businesses rely on wholesale suppliers to provide high-quality anatase titanium dioxide for their coating applications.

Titanium is a common metal element frequently found throughout nature. In our environment, titanium is naturally exposed to oxygen, forming titanium oxides that we find in many minerals, dusts, sands, and soils.

In a study published in the journal Food and Chemical Toxicology in 2016, researchers investigated whether titanium dioxide exposure led to an increase in colorectal tumor creation in mice by using a colitis associated cancer model. By measuring tumor progression markers, the researchers found that mice given titanium dioxide experienced enhanced tumor formation in the distal colon.  There was also a decrease of cells that act as a protective barrier in the colon. The researchers wrote: “These results suggest that E171 could worsen pre-existent intestinal diseases.”

In a 2019 study published in the journal Nanotoxicology, researchers recreated the first phase of digestion in mice and fed them titanium dioxide, then examined whether accumulation occurred in the organs. Researchers wrote: “Significant accumulation of titanium was observed in the liver and intestine of E171-fed mice; in the latter a threefold increase in the number of TiO2 particles was also measured. Titanium accumulation in the liver was associated with necroinflammatory foci containing tissue monocytes/macrophages. Three days after the last dose, increased superoxide production and inflammation were observed in the stomach and intestine. Overall, [this] indicates that the risk for human health associated with dietary exposure to E171 needs to be carefully considered.”

Edelweiss, 14.5 per cent zinc sulphide, 84 per cent barium sulphate, 1.5 per cent carbonate of lime.

In general, nanoparticles have been shown to accumulate in the body, particularly in organs in the gastrointestinal tract, along with the liver, spleen, and capillaries of the lungs.