A 2023 study published in the journal Particle and Fibre Toxicology set out to examine the impact of titanium dioxide nanoparticles in mice “on the course and prognosis of ulcerative colitis,” by creating an ulcerative colitis disease model. Researchers found that the titanium dioxide nanoparticles significantly increased the severity of colitis. They also “decreased the body weight, increased the disease activity index and colonic mucosa damage index scores, shortened the colonic length, increased the inflammatory infiltration in the colon.” Researchers concluded: “Oral intake of TiO2 nanoparticles could affect the course of acute colitis in exacerbating the development of ulcerative colitis, prolonging the ulcerative colitis course and inhibiting ulcerative colitis recovery.”
Lithopone 30% is the perfect solution for partial substitution of TiO2 in fillers due to its very soft nature and hardly any shrinkage properties.
Genotoxicity Assessment
Basic Information:
As a widely used substance with multiple applications, research is being carried out to improve the production process to reduce the levels of chemicals used and waste produced, and to recycle any by-products.
PRINCIPALES UTILISATIONS
Item
≥105
2. Hazard identification The MSDS should outline any potential hazards associated with the handling and use of lithopone. This includes information on the physical and chemical properties of the product, as well as any potential health hazards or environmental risks.
It should also be considered that due to the low pH in the stomach, the increased dissolution of the TiO2 particles may increase its bioavailability and may facilitate the entry of titanium ions into the blood circulation. Despite the relatively large consumption of TiO2 as a food additive, no studies on the effect of pH on its absorption and bioavailability have been found in the literature. This can be attributed to a general belief that TiO2is completely insoluble. However, this is not completely true, as TiO2 particles show a certain degree of solubility.

