(7) Compatibility with other ingredients:
HPMC is known for its compatibility with a variety of active ingredients and excipients commonly found in vitamin formulations. This makes it a versatile choice for manufacturers looking to create complex recipes with multiple ingredients.

Answer: hot water solution method: because HPMC is not dissolved in hot water, so the initial HPMC can be evenly dispersed in hot water, then quickly dissolved when cooling, two typical methods are described as follows:
1) Put the required amount of hot water in the container and heat it to about 70℃. Under the slow stirring gradually add hydroxypropyl methyl cellulose, HPMC began to float on the surface of the water, and then gradually form a slurry, the slurry cooling under the stirring.
2) Add 1/3 or 2/3 of the required amount of water into the container, and heat to 70℃, according to the method of 1), disperse HPMC, prepare hot water slurry; Then add the remaining amount of cold water to the hot slurry, stirring and cooling the mixture.
Powder mixing method: HPMC powder and a large number of other powdery material ingredients, mixing fully with a blender, then add water to dissolve, HPMC at this time can dissolve, and do not stick together, because each small corner, only a little bit of HPMC powder, water will dissolve immediately. - Putty powder and mortar production enterprises are using this method. [Hydroxypropyl methyl cellulose (HPMC) is used as thickening agent and water retaining agent in putty mortar.]

Application

For hydroxypropyl cellulose (E 463), the identified NOAEL corresponded to the highest dose 6,000 mg hydroxypropyl cellulose/kg bw per day (by gavage). The most relevant feeding studies with HPMC (E 464) were performed in rats which tolerated up to 10%, corresponding to 9,000 mg test item/kg bw per day. Rabbits tolerated up to 7,500 mg HPMC/kg bw per day administered via the diet (30 day exposure) and dogs up to 1,500 mg HPMC/kg bw per day, in either case being the highest tested dosages. More studies were conducted using sodium carboxy methylcellulose (E 466). The most relevant ones were conducted in rats, with NOAEL values ranging from 4,500 to 9,000 mg test item/kg bw per day (in all cases the highest dose tested). In these studies, some effects (caecum and colonic enlargement, urothelial hyperplasia, nephrocalcinosis, diffuse epithelial hyperplasia in the urinary bladder) were observed, however, not considered of toxicological concern: the findings in the gastrointestinal tract were considered to be a consequence of the accumulation of poorly absorbed water-soluble material and the findings in kidneys and urinary bladder were attributed to the up to fourfold higher concentration of sodium in the test diet compared with the basal diet. In one further study, rats were daily exposed (gavage) to doses equivalent to 0, 500, 2,500 or 5,000 mg/kg bw per day. Animals treated with ≥ 2,500 mg/kg bw per day had soft and pale faeces, which was attributed to the presence of test material and not considered of toxicological relevance. In the absence of any other adverse effects, also for this study, the identified NOAEL was the top dose (5,000 mg/kg bw per day).

Dispersion: the dispersion of HPMC is better than HEC. But HEC has a stronger protective colloid than HPMC.

Why take capsule products?