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Relative to a lot of other things that people should be concerned about, titanium dioxide in my mind, is really low on the list. I would be more worried about some substitutes that people are using for titanium dioxide that don't have decades of research associated with it, said Westerhoff.


It's also used in sunscreens as a UV filtering ingredient, helping to protect a person's skin by blocking absorption the ultraviolet light that can cause sunburn and cancer.
In industrial settings, people can be exposed to titanium dioxide through inhalation. Inhalation exposure to titanium dioxide is exceedingly rare for most people.
It’s also used in food products to provide a white color. Candies, cakes and creamers are examples of foods that may contain titanium dioxide for its color enhancing and bleaching properties.
How are we typically exposed to titanium dioxide?
Fig. 4. Hemolysis (%) values of samples, A: 0.2 mg/mL P25TiO2NPs; B: 0.02 mg/mL P25TiO2NPs; C: 0.2 mg/mL VitaminB2@P25TiO2NPs; D: 0.02 mg/mL VitaminB2@P25TiO2NPs after 3 h of irradiation (red) and 6 h (blue). SD <5 for all samples and p <0.05 between C-D and A-B.
A 2023 study published in the journal Environmental Research, scientists examined the effect of titanium dioxide nanoparticles on important gut bacteria in mice. Their results showed “the growth inhibitory effects could be associated with cell membrane damage caused by titanium dioxide nanoparticles to the bacterial strains. Metabolomics analysis showed that TiO2 NPs caused alterations in multiple metabolic pathways of gut bacteria, such as tryptophan and arginine metabolism, which were demonstrated to play crucial roles in regulating gut and host health.” The researchers also found that four different neuroprotective metabolites “were significantly reduced” in urine and in vitro bacteria and vivo urine samples. The researchers concluded: “Increasing evidence implies that the gut microbiome plays a profound role in regulating host metabolism. Our results illustrated that TiO2 NPs hindered the growth of four beneficial gut bacterial strains.”

Even though it is one of the most-produced chemicals, the real and potential benefits of titanium dioxide are not without controversies. Dust inhalation may cause breathing problems. Titanium dioxide has been classified by the International Agency for Research on Cancer as an Group 2B carcinogen, a “possible carcinogen to humans,” based on studies of rats that inhaled the substance.
In the European domestic market, however, the cost support from increasing freight charges kept the valuation of imported volumes high, and the average CFR NWE discussions were assessed at USD 3800 per tonne in the fourth quarter of 2021.
TiO2 comes in many different forms. However, only a few of these forms are considered food-grade (acceptable to be added to food). Many studies that raised concern about the safety of TiO2, including the concern for genotoxicity, used forms of TiO2 that are not considered acceptable for use in food and have different properties than food-grade TiO2. Other studies did use food-grade TiO2, but took steps to break the material down into smaller particles than what would normally be found in food.